Universitą degli studi di Pavia


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Prof. Mauro Freccero
e-mail: mauro.freccero@unipv.it
Phone number: +390382987668

Mauro Freccero, born in 1966, Savona, Italy.
Associate Professor; Head of an Organic Synthesis Unit at Pavia University, Italy, since 2002.
Post-doctorate, at Dublin City University, Dublin (Ireland) (1994-1995)
Ph.D. in Organic Chemistry (University of Pavia, 1993)
Degree in Chemistry (cum laude, University of Pavia, 1990)

Professional career
Head of the Ph.D. School in Chemical and Pharmaceutical Sciences at Pavia University, since 2013.
Associate Professor at Pavia University since 2002.
Assistant Professor (1996-2001).
Post-doctorate (beginning of 1996) at the Dept. of Organic Chemistry, Pavia University.
Two-year post doctorate at Dublin City University, Dublin (Ireland) (1994-1995).
R&D Chemist, at ACSDobfar S.p.A., fine chemicals, MI (beginning of 1994).
Visiting Scientist, Dep. of Chemistry & Biochemistry, University of Maryland USA (1993).
Ph.D in Chemistry (1990-1993).
Degree in Chemistry (110/110 cum laude) at the University of Pavia (1990).

I have authored 83 publications in peer review international journals (H-index 25, SciFinder; citations 1566 (Scopus)) including a chapter entitled “Modeling properties and reactivity of quinone methides” in the book Wiley Series on Reactive Intermediates in Chemistry and Biology 2009, 1 (Quinone Methides), 33-67.

Research interests. My current research interest is focused on organic synthesis and binding properties of new G-quadruplex selective ligands, targeting human telomeres and oncogenes, for theranostic applications (targeted anticancer therapy and fluorescence emission diagnostic). In addition, I developed a solid expertise in transient, activatable and selective reactants targeting DNA.

Most important and active financed projects.
I am directing the synthetic unit of a 2009-2015 FIRB-IDEAs (MIUR: Italian Ministry of Education, University and Research). Project entitled “New drug for anticancer targeted therapy” (RBID082ATK_003, gross funding 480.000 €).
2011-2013. Principal investigator, PRIN2009 (MIUR). Project entitled “Selective Molecular Devices Targeting "G-Quadruplexes" (2009MFRKZ8; gross funding: 250.573 €).
2013-2016. Principal investigator AIRC-IG (the Italian Association for Cancer Research). “Photoactive molecules targeting telomeric G-quadruplex as multimodal agents in anticancer therapy”. (IG 2013 N.14708, gross funding 265.000 €).
2014-2019. 7th FRAMEWORK PROGRAMME. Consolidator Grant. “HIV LTR G-4. Grant agreement no615879. G-quadruplexes in the HIV-1 genome: novel targets for the development of selective antiviral drugs”. “Second beneficiary (gross funding 659.604 €) of a Multi-beneficiary contract”.

Teaching experiences. Organic Chemistry III and Laboratory for chemists (an advanced course, since 2001). Organic Chemistry for Biotecnology (since 2001), both at Pavia University. Organic Chemistry for Biotecnology, and Chemistry for the International MD Program (in English) at UniSR (Universitą Vita-Salute San Raffaele), Milan, Italy, since 2010.

List of 10 recent and important publications.
1) Doria, F.; Nadai, M.; Folini, M.; Scalabrin, M.; Germani, L.; Sattin, G.; Mella, M.; Palumbo, M.; Zaffaroni, N.; Fabris, D.; Freccero, M.;* Richter, S. N.* Targeting Loop Adenines in G-Quadruplex by a Selective Oxirane. Chem. Eur. J. 2013, 19, 78–81.
2) Petenzi, M.; Verga, D.; Largy, E.; Hamon, F.; Doria, F.; Teulade-Fichou, M.-P.; Guedin, A.; Mergny, J.-L.; Mella, M.; Freccero, M.* Cationic Pentaheteroaryls as Selective G-Quadruplex Ligands by Solvent-Free Microwave-Assisted Synthesis. Chem. Eur. J. 2012, 18, 14487-14496.
3) Doria, F.; Nadai, M.; Sattin, G.; Pasotti, L.; Richter, S. N.; Freccero, M.* Water soluble extended naphthalene diimides as pH fluorescent sensors and G-quadruplex ligands. Org. Biomol. Chem., 2012, 10, 3830–3840. http://pubs.rsc.org/en/content/articlepdf/2012/OB/C2OB07006E
4) Doria, F.; Nadai, M.; Folini, M.; Di Antonio, M.; Germani, L.; Percivalle, C.; Sissi, C.; Zaffaroni, N.; Alcaro, S.; Artese, A.; Richter, S. N.; Freccero, M.* Hybrid ligand–alkylating agents targeting telomeric G-quadruplex structures. Org. Biomol. Chem., 2012, 10, 2798–2806.
5) Doria, F.; Percivalle, C.; Freccero, M.* Vinylidene-Quinone Methides, Photochemical Generation and β-Silicon Effect on Reactivity. J. Org. Chem. 2012, 77, 3615−3619. http://pubs.acs.org/doi/pdf/10.1021/jo300115f?source=chemport
6) Nadai, M.; Doria, F.; Di Antonio, M.; Sattin, G.; Germani, L.; Percivalle, C.; Palumbo, M.; Richter, S. N.; Freccero, M.* Naphthalene diimide scaffolds with dual reversible and covalent interaction properties towards G-quadruplex. Biochimie 2011, 93, 1328-1340.
7) Verga, D.; Nadai, M.; Doria, F.; Percivalle, C.; Di Antonio, M.; Palumbo, M.; Richter, S. N.; Freccero, M.* Photogeneration and Reactivity of Naphthoquinone Methides as Purine Selective DNA Alkylating Agents. J. Am. Chem. Soc. 2010, 132, 14625–14637.
8) Doria, F.; Di Antonio, M.; Benotti, M.; Verga, D.; Freccero, M. Substituted Heterocyclic Naphthalene Diimides with Unexpected Acidity. Synthesis, Properties, and Reactivity. J. Org. Chem. 2009, 74, 8616–8625. http://pubs.acs.org/doi/pdf/10.1021/jo9017342?source=chemport
9) Di Antonio, M.; Doria, F.; Richter, S. N.; Bertipaglia, C.; Mella, M.; Sissi, C.; Palumbo, M.; Freccero, M.* Quinone Methides Tethered to Naphthalene Diimides as Selective G-Quadruplex Alkylating Agents. J. Am. Chem. Soc. 2009, 131, 13132-13141.
10) Doria, F; Richter, S. N.; Nadai, M.; Colloredo-Mels, S.; Mella, M.; Palumbo, M.; Freccero, M.* BINOL-Amino Acid Conjugates as Triggerable Carriers of DNA-Targeted Potent Photocytotoxic Agents. J. Med. Chem. 2007, 50, 6570–6579. http://pubs.acs.org/doi/pdf/10.1021/jm070828x?source=chemport

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