Università degli studi di Pavia


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Courses 2016

Curriculum: Chemistry

Materials and devices for energy storage and management (6 CFU)

Prof: G. Spinolo

The main topics are: Defects in crystalline solids; overview of crystalline electrolytes; Basic aspects of Solid state electrochemistry; Polymer electrolytes; Fuel cells; Electrochemical sensors; Semiconductor sensors.
Course duration: 22 hours.
Final evaluation: Oral exam.

Sensors, biosensors and electronic noses
(6 CFU)

Prof: M. Pesavento, R. Biesuz

Chemo and biosensors are based on the interaction between the molecule of interest and a suitable receptor. The sensor is constituted by the integration of the adduct formation with the transduction of the signal generated by the interaction. Some of the presently most used receptors will be described, i.e. biomolecules as proteins (antibodies, enxymes) and nucleic acids (DNA, RNA, aptamers). A particular kind of synthetical solid receptors, i.e. the molecularly imprinted polymers (MIP) will be presented too. MIPs represent an interesting class of biomimetic receptors, with noticeable benefits with respect to the biological molecules. The most used transduction techniques, both based on markers and label-free, will be briefly described.
A very good selectivity is obtained using the bio or biomimetic receptors. A different approach is based on the simultaneous use of several sensors not very specific. Devices of this kind are often indicated as “electronic noses” or “electronic tongues”, depending on the phase in which the determination is carried out. The responses of the single sensor are analyzed by chemometric approaches. Some methods will be presented.
The course is constituted by 24 hours.
Final exam: presentation and discussion of a recent research paper concerning the issues of the course.

Current development in catalysis research: Modern arylation methods
(6 CFU)

Prof: L. Ackermann (Institute of Organic and Biomolecular Chemistry, Georg-August-University Göttingen)

The course program is focused on three main research areas: (A) catalytic functionalization of unactivated C-H bonds. This work includes the use of inter alias rutenium, titanium, zirconium, nickel and copper catalysts on a day to day basis; (B) development of air-stable secondary phosphine oxides as preligands for catalytic cross-couplings; and (C) hydroaminations of alkynes, allenes and alkenes.

Curriculum: Pharmaceutical Sciences

DOE: Application to pharmaceutical formulations (2 Credits)

Prof. Maria Cristina Bonferoni

Contents: The first part of the course will consider factorial and screening designs aimed at finding critical variables of methods, processes and formulations. The second part will deal with optimization methods. Response surface designs and mixture designs will be considered to find the region where optimal response can be obtained. Different examples of pharmaceutical applications will be studied. Attention will be paid to the application of DOE in the more recent regulatory approach to the pharmaceutical quality. Some examples will be analyzed with a computer specific software. Learning check: discussion of a report on two case studies.

Innovative analytical methods in drug discovery (4 Credits)

Prof. Enrica Calleri

Contents: Study of the most important and innovative analytical techniques used in drug discovery for the determination and characterization of drug-protein binding (separative and non-separative methods). Objectives of the course are: 1) make the students familiar with the theoretical basis of the most recent techniques and analytical methodologies used in the different steps of the drug discovery process (bioaffinity methods, methods based on mass spectrometry, ITC methods, luminescence methods etc.). 2) case studies presentation. Seminars will be also organized and given by experts operating in the drug discovery field. Learning check: written tests.

Production and characterization of active pharmaceutical ingredients and excipients (4 credits)

Prof. Carla M. Caramella

Contents: Drug Master File (DMF): how to present information on Active Pharmaceutical Ingredients (API)). API and excipients reported in the European Phamacopoeia: the certificate of compliance (CEP) to the Pharmacopoeia. API synthesis: the problem of raw materials and impurities.. Excipients and impurities. Production of API and Good Manufacturing Practices. Production of sterile APIs. Learning check: written examination.

From hit identification to lead optimization (4 Credits)

Prof. Simona Collina

Contents: This two-days course focuses on the drug discovery process, from the identification of novel drug targets to the identification of a drug candidate. The drug discovery process starts with the identification of compounds (one or more, name hit compounds), with either natural or synthetic origin, endowed with promising biological properties. Such compounds will successively undergo further studies aimed at turning hit into lead (hit-to-lead process). In this phase hit(s) are structurally modified in order to improve their pharmacodynamic, pharmacokinetic and toxicological profiles. The final output of hit-to-lead process is the drug candidate. Theoretical lessons are combined with practical case studies. Learning check: written examination.

Manufacturing of sterile pharmaceutical products (4 credits)

Prof. Bice Conti

Contents: General aspects of sterile pharmaceutical products. Sterility assurance: design and qualification of aseptic areas in compliance with regulatory requirements (GMP). Technology transfer of sterile pharmaceutical products. Risk assessment in sterility assurance. Microbiologic control assessment. “Process simulation testing” applied to aseptic processes. Isolators and containment. Learning check: written examination.

Multivariate statistical analysis (2 Credits)

Prof. Maria Daglia

Contents: 1) Design of Experiment (DOE) as the best strategy for efficient experimentation; applications in the formulation development and analytical control of nutraceuticals. 2) Experimental design for a selection of homogeneous samples for a study of shelf-life. Multivariate statistical methods for analysis of chemical, physical and sensorial responses sampled in time; 3) Innovative approaches for the determination of the characteristics of nutraceuticals, with particular attention to metabolomic studies through LC/MS and NMR. 4) In silico models for the study of nutraceutical biological activities. 5) Multivariate Statistical Process Control (MSPC). Learning check: written examination.

Physical properties of powders (2 Credits)

Prof. Franca Ferrari

Contents: The characterization of particle size distribution of a multiparticulate system is of interest to many branches of learning: chemistry, pharmaceutical technology, chemical engineering. As for the pharmaceutical field, such a characterization it is important in three different moments: preformulation studies, manufacturing processes, biopharmaceutical properties of dosage forms. The course deals with fundamental (size, shape, surface area) and derived (packing, flow) properties of powders and the relevant analytical techniques. Theoretical lessons are implemented by many case studies. Learning check: written examination.

Rational drug design (4 credits)

Prof. Daniela Rossi

Contents: This two-days course is concerned with enabling students to molecular modeling techniques useful for the rational design of biologically active molecules (Computer Aided Drug Design - CADD). The course focus on both ligand-based (QSAR, pharmacophore modeling) and structure-based (molecular docking, homology modeling and virtual screening) drug design methodologies. Additionally, in silico prediction of ADMET properties is considered. The course is composed by theoretical lessons (2CFU) combined with hand-on section Learning check: written examination.

Technological controls of drug delivery systems (2 Credits)

Prof. Silvia Rossi

Contents: The course aims at providing an advanced knowledge of the technological controls of drug delivery systems with particular attention to liquid and semisolid formulations. Great importance will be devoted to viscosity and viscoelastic measurements, functional to characterization and formulation development of the above mentioned formulations. Suitable tests employed to evaluate mechanical and biopharmaceutical properties of liquid and semisolid formulations will also be treated. The theoretical explanation of the topics will be accompanied by the discussion of case studies. Learning check: oral examination.

Patent low (2 Credits)

Teacher: Lauretta Maggi

Scheduled period: June–July Aim: provide a theoretical and practical guideline to patent an invention in the pharmaceutical chemical and biotechnological fields. Some possibilities for the technological transfer of the product will be considered. Spin-off and start-up. Content: Introduction on the intellectual property rights in the modern society. Patentability requirements of an invention. Evaluation of the potential costs and limitations of a patent. Search report and on-line database. Procedures to file a national or international patent. Procedures for examination, extension, possible opposition or patent infringement. Regional and international organizations: European Patent Office, Patent Cooperation Treaty, Word Intellectual Property Organization. Final evaluation: written
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